22 research outputs found
Load Balancing in Tree-based IP Micro-Mobility Domains
Nowadays the penetration of wireless access is continuously increasing.
Additionally, the mobile users become more and more dependent on data. The
IP-based (Internet Protocol) Internet was designed for data transmission and
has become the most ubiquitous wired internetwork. According to these trends
the next generation networks (and already 3G networks also include IP-based
parts) are designed as a combination of these two types of networks (mobile
and IP-based). The Mobile IP protocol handles mobility in the IP layer
globally, but it is not well-adopted to local coverage areas. Within such
access networks the micro-mobility proposals enhance the performance of
Mobile IP. In this paper we propose a solution for improving the performance
of tree-based micro-mobility protocols by rearranging their capacity using
additional links. Based on analytical considerations we obtain a formula to
determine the optimal link size in particular cases. The method is also
examined with our simulation testbed, the results show improvement in the
performance of the domain
Atipikus hatósági tevékenység és döntéshozatal, különös tekintettel az új közigazgatási rendtartásra = The Atypical Activity and Decision-Making of the Administrative Authorities with Special Regard to the New Act on the Administrative Proceedings
2018. január 1-jĂ©vel hatályba lĂ©p a közigazgatási hatĂłsági eljárást ĂşjrakodifikálĂł általános közigazgatási rendtartásrĂłl szĂłlĂł 2016. Ă©vi CL. törvĂ©ny, amely alapjaiban változtatja meg a közigazgatási hatĂłsági eljárás jelentĹ‘sebb jogintĂ©zmĂ©nyeit. Jelen tanulmány a közigazgatási hatĂłságok atipikus cselekmĂ©nyei, illetve döntĂ©shozatali formái mellett, az illetĂ©kessĂ©g hiányában törtĂ©nĹ‘ eljárást vizsgálja. A kutatás keretein belĂĽl feldolgozták a sommás eljárásra, a fĂĽggĹ‘ hatályĂş döntĂ©sre, illetve a hatĂłsági bizonyĂtványra, igazolványra, nyilvántartásra, valamint a hatĂłsági ellenĹ‘rzĂ©sre vonatkozĂł szabályozást. A tanulmány egyrĂ©szt tudományos igĂ©nnyel, elmĂ©leti szempontbĂłl közelĂt nevezett jogintĂ©zmĂ©nyekhez, másrĂ©szt vizsgálja azok gyakorlati Ă©rvĂ©nyesĂĽlĂ©sĂ©t is.
On the 1st of January 2018 the Act on the Administrative Proceedings takes effect, which basically changes the most important legal institutions of the administrative procedure. This paper examines the procedures of atypical acts and decision-making of the administrative authorities as well as their procedures in the absence of jurisdiction. Within the framework of the research the regulations concerning the summary procedure, the pending decision, the official certificate, the official card, the official register and the official control were processed. The study, on the one hand, approaches said legal institutions with a scientific need from a theoretical point of view. On the other hand it also examines their practical effectiveness
Szemelvények a Semmelweis Egyetem, az Országos Onkológiai Intézet és az Országos Korányi Tbc és Pulmonológiai Intézet együttműködésén alapuló tüdőrák-kutatási programból
Lung cancer places a significant socio-economic burden on the Hungarian population. This overview summarizes the findings of collaborative translational lung cancer research efforts of three Hungarian flagship academic institutions, the Semmelweis University, the National Institute of Oncology and the National Koranyi Institute of TB and Pulmonology. With regards to the molecular factors regulating tumor angiogenesis, we identified the prognostic significance of apelin and erythropoietin receptor (EPOR) expression in non-small cell lung cancer (NSCLC). Furthermore, the impact of KRAS mutation subtypes and ERCC1 (excision repair cross-complementation group 1) expression on the response to platinum-based chemotherapy have been studied. We also described the epidemiology and predictive power of rare EGFR (epidermal growth factor receptor) mutations in a large Hungarian patient cohort. Lastly, the expression of molecular factors associated with NSCLC progression was studied specifically in brain metastatic matched cases series. These preclinical and clinical studies provide clinically relevant information that hopefully will contribute to the improvement of lung cancer patient care
A COVID–19-járvány hatása a leggyakoribb légzőszervi megbetegedések lefolyására
Bevezetés: A SARS-CoV-2 által okozott fertőzés az elmúlt három évben meghatározta mindennapi életünket, és nem
várt terhet rótt az egészségügyi ellátórendszerre, többek között azáltal, hogy komoly kockázati tényezőt jelenthet a
már meglévő, különböző légzőszervi megbetegedésekkel küzdő betegek számára is.
Célkitűzés: A COVID–19 és a fertőzéskor már fennálló légzőszervi megbetegedések, elsősorban a krónikus obstruk-
tĂv tĂĽdĹ‘betegsĂ©g (COPD), valamint az asztma összefĂĽggĂ©seinek feltárása.
MĂłdszer: Hazai vizsgálatunkban közel 29 000 beteg adatait dolgoztuk fel retrospektĂven.
EredmĂ©nyek: EredmĂ©nyeink alapján elmondhatĂł, hogy a COPD mint társbetegsĂ©g meglĂ©te a nemzetközi megállapĂ-
tással egybehangzĂłan összefĂĽggĂ©st mutat a COVID–19-fertĹ‘zĂ©s sĂşlyosságával, illetve enyhĂ©n növeli az intenzĂv osz-
tályos kezelés és a gépi lélegeztetés szükségességének kockázatát a SARS-CoV-2 okozta megbetegedés során. Asztma
esetĂ©ben mindezt nem sikerĂĽlt kimutatnunk, vagyis sem a SARS-CoV-2-fertĹ‘zĂ©s sĂşlyosságát, sem az intenzĂv osztá-
lyos kezelés és a gépi lélegeztetés szükségességét nem befolyásolta jelentősen az asztma mint társbetegség megléte.
MegbeszĂ©lĂ©s: Ahogy nemzetközi tanulmányokban is olvashatĂł, a COPD mint társbetegsĂ©g meglĂ©te nem növeli jelentĹ‘s mĂ©rtĂ©kben a SARS-CoV-2-fertĹ‘zĂ©s kockázatát. Ugyanakkor kijelenthetĹ‘, hogy a COPD növeli a COVID–19-pozitĂv betegek kĂłrházba kerĂĽlĂ©sĂ©nek esĂ©lyĂ©t, Ă©s emeli a megbetegedĂ©s sĂşlyosabb lefolyásának valĂłszĂnűsĂ©gĂ©t. Tekintettel a COPD-betegekben a tĂĽdĹ‘ károsodása során vĂ©gbemenĹ‘ szerkezeti átĂ©pĂĽlĂ©sre Ă©s rendellenes regenerálĂłdási folyamatokra, e betegek a vĂrusfertĹ‘zĂ©s lezajlása után fokozott odafigyelĂ©st, valamint szemĂ©lyre szabott rehabilitáciĂłt igĂ©nyelnek.
KövetkeztetĂ©s: Ă–sszessĂ©gĂ©ben elmondhatĂł, hogy a jövĹ‘ben a szemĂ©lyre szabott terápiás megközelĂtĂ©s bevezetĂ©sĂ©hez
elengedhetetlen a kĂĽlönbözĹ‘ COPD-s fenotĂpusok (valamint egyĂ©b krĂłnikus tĂĽdĹ‘betegsĂ©gek) Ă©s a SARS-CoV-2-fer-
tőzés klinikai megnyilvánulásainak mélyreható vizsgálata
Fibulin-3 levels in malignant pleural mesothelioma are associated with prognosis but not diagnosis
BACKGROUND: Fibulin-3 (FBLN3) was recently presented as a promising novel biomarker for malignant pleural mesothelioma (MPM), warranting independent validation studies. METHODS: ELISA was used to measure cellular and secreted FBLN3 in cell lines, in plasma of xenograft tumour-bearing mice, in plasma from two independent series of MPM and non-MPM patients and in pleural fluid from a third series. Diagnostic and prognostic potential of FBLN3 was assessed by receiver operating characteristics curve analysis and Kaplan-Meier method, respectively. RESULTS: FBLN3 was expressed in all MPM and benign mesothelial cell lines tested, and a correlation was observed between cellular protein expression and secreted levels. Human FBLN3 was detectable in plasma of tumour-bearing mice, suggesting that MPM cells contribute to levels of circulating FBLN3. Plasma FBLN3 was significantly elevated in MPM patients from the Sydney cohort, but not the Vienna cohort, but the diagnostic accuracy was low (63%, (95% CI: 50.1-76.4) and 56% (95% CI: 41.5-71.0), respectively). Although FBLN3 levels in pleural effusions were not significantly different between cases and controls, FBLN3 levels in pleural effusion fluid were found to be independently associated with prognosis (hazard ratio of 9.92 (95% CI: 2.14-45.93)). CONCLUSIONS: These data confirm the potential prognostic value of pleural effusion FBLN3, but question the diagnostic value of this protein in MPM patients
High circulating activin A level is associated with tumor progression and predicts poor prognosis in lung adenocarcinoma
Activin A (ActA)/follistatin (FST) signaling has been shown to be deregulated in different tumor types including lung adenocarcinoma (LADC). Here, we report that serum ActA protein levels are significantly elevated in LADC patients (n=64) as compared to controls (n=46, p=0.015). ActA levels also correlated with more advanced disease stage (p<0.0001) and T (p=0.0035) and N (p=0.0002) factors. M1 patients had significantly higher ActA levels than M0 patients (p<0.001). High serum ActA level was associated with poor overall survival (p<0.0001) and was confirmed as an independent prognostic factor (p=0.004). Serum FST levels were increased only in female LADC patients (vs. female controls, p=0.031). Two out of five LADC cell lines secreted biologically active ActA, while FST was produced in all of them. Transcripts of both type I and II ActA receptors were detected in all five LADC cell lines. In conclusion, our study does not only suggest that measuring blood ActA levels in LADC patients might improve the prediction of prognosis, but also indicates that this parameter might be a novel non-invasive biomarker for identifying LADC patients with organ metastases